The rare and inexplicable Puberty Syndrome is thought of as a myth. It is a rare disease that only affects teenagers, and its symptoms are so supernatural that hardly anyone recognizes it as a legitimate occurrence. However, high school student Sakuta Azusagawa knows from personal experience that it is very accurate and quite prevalent in his school.

Mai Sakurajima is a third-year high school student who gained fame in her youth as a child actress but recently halted her promising career for reasons unknown to the public. With an air of unapproachability, she is well-known throughout the school. Still, no one dares interact with her until Sakuta sees her wandering the library in a bunny girl costume. Despite the getup, no one seems to notice her, and after confronting her, he realizes that she is another victim of Puberty Syndrome. As Sakuta tries to help Mai through her predicament, his actions bring him into contact with more girls afflicted with the elusive disease.